Understanding how cells transform into specialized types during human development is a central challenge in biology. This complex process, known as cell differentiation, holds the key to understanding ...

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the ...

T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

There is a high unmet need for accessible, affordable, and high-quality fertility care, as approximately 1 in 6 people are affected by infertility worldwide. While meiotic failure is a major cause of ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Understanding how cells transform into specialized types during human development is a central challenge in biology. This complex process, known as cell differentiation, holds the key to understanding ...

Tooth root development relies on precise coordination of cellular signals, yet the underlying mechanisms remain unclear. Researchers have uncovered how two proteins, Gli2 and Gli3, work together to ...

More than 60 years after its discovery, scientists are still learning surprising ways DNA stores and translates instructions ...

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and potential therapeutic targets. The team used their reference map for normal ...

B-cell acute lymphoblastic leukemia is the most common form of childhood cancer. In this type of cancer, which affects blood cells, one of the most common abnormalities is the presence of cells with ...

Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion ...